Embark your ship and settle into your stateroom. The birthplace of American jazz, New Orleans exudes a festive atmosphere along the balcony-lined Bourbon Street. Here, in the heart of the French Quarter, soulful rhythms lift the spirit, especially during the city’s Mardi Gras celebration. Founded by French colonists in 1718, New Orleans served as a territorial capital before the Louisiana Purchase of 1803. Its distinctive St. Louis Cathedral—named for King Louis IX of France—is the oldest cathedral in the country. The city’s French, African and other influences flavor its vibrant culture and tantalizing Creole cuisine.

Day 2: Darrow, Louisiana

The Lower Mississippi region is dotted with historic mansions; Darrow is the gateway to these grand homes, meticulously kept to preserve the memory of early Southern American history. Here, imposing houses share the riverscape with moss-draped oak trees and farm fields. It is easy to imagine steamboats and other vessels delivering supplies and materials to these stately front doors. Today, several properties are designated National Historic Landmarks for their architecture, their landscaping, and the contributions of those who maintained the houses and the lands.

Day 3: St. Francisville & Baton Rouge, Louisiana

Boasting more than 140 buildings on the National Register of Historic Places, St. Francisville is set along one of the most historic bluffs of the Mississippi. The town is said to be “two miles long and two yards wide” because it was originally built on a narrow ridge overlooking the river. Founded in 1809, it is the oldest town in Louisiana’s Florida Parishes. Remarkably, many of St. Francisville’s structures are not its own; rather, they were moved upriver from Bayou Sara in the 1920s after the small settlement was destroyed by years of flooding.

Baton Rouge paints a historic picture on the eastern bank of the Mississippi. Its early success was due to its flood-free location upon the first natural bluff north of The Delta. French explorer Pierre Le Moyne, Sieur d’Iberville, named the city after a red-hued pole that marked the area’s tribal hunting grounds. Its cultural diversity—from its Cajun and Creole music and cuisine to its art offerings—reflects the influences of those who settled and lived here throughout Baton Rouge's history. The city boasts the tallest capitol building in the United States.

Day 4: Natchez, Mississippi

Natchez has one of the highest concentrations of historic Southern estates in the country. More than 200 perfectly preserved homes line its avenues. It is the oldest city on the Mississippi, established in 1716 by French colonists and named for the Natchez tribe who once called it home. With its ideal locale, the city became a crossroads among Native American and European cultures. Famously, Natchez was the southern terminus of the Natchez Trace, the overland route to Nashville that allowed traders to bypass the strong upriver currents. Today, it evokes small-town America.

Day 5: Vicksburg, Mississippi

Located on a high bluff where the Yazoo River flows into the Mississippi, Vicksburg is the epitome of Southern heritage and charm. It was incorporated in 1825 and, with its prime locale on the Mississippi, grew into an important port. During the Civil War, Abraham Lincoln called it “the key to the South.” And it indeed proved to be the site of the conflict’s most pivotal battle, the Battle of Vicksburg, after which the Confederates surrendered to Ulysses S. Grant. The Vicksburg National Military Park preserves the battle site’s rolling green fields and grand monuments.

Day 6: Greenville, Mississippi

Greenville is Mississippi’s largest river port, set atop the highest point along the Mississippi River between Vicksburg and Memphis. Its rural setting belies a diverse artistic heritage. The Muppets creator Jim Henson was born here, and the city has been home to numerous authors, including noted historian Shelby Foote. Greenville is also steeped in the blues; famed songwriter W.C. Handy was inspired to popularize the genre after seeing pioneering musician Prince McCoy perform at a nearby dancehall and neighboring Indianola was the hometown of the legendary B.B. King.

Day 7: Scenic Sailing Lower Mississippi

Teeming with a wide variety of birdlife and a breathtaking array of picturesque landscapes—including deep-green forests, lush wetlands and a patchwork of fertile farmlands—the Lower Mississippi abounds with natural beauty. This portion of America’s great waterway is also rich in history and culture, as reflected in the classic literature and music that have drawn inspiration from it.

Day 8: Memphis, Tennessee

After breakfast, disembark your ship and journey home.